Optimized Conditions for Producing Epothilone via Fermentation of Sorangium cellulosum

Journal of South China University of Technology (Natural Science Edition) ›› 2006, Vol. 34 ›› Issue (5): 48-52.

• Biological Engineering • Previous Articles Next Articles

Optimized Conditions for Producing Epothilone via Fermentation of Sorangium cellulosum

Luo Li-xin Wang Wei Lu Yi-ming Pan Li Sa Si-lin Kong Jun-wen

College of Biological Scienc and Engineering,South China Univ.of Teeh.,Guangzhou 510640,Guangdong,China

Received:2005-06-30 Online:2006-05-25 Published:2006-05-25
Contact: 罗立新(1966-)，男，副教授，博士，主要从事微生物制药和生物化工研究． E-mail:btlxluo@scut.edu.cn
About author:罗立新(1966-)，男，副教授，博士，主要从事微生物制药和生物化工研究．
Supported by:
广东省自然科学基金资助项目(031357)

Abstract

Abstract:

This paper focuses on the production of epothilone,a kind of secondary anti-cancer metabolite fermented by Sorangium cellulosum DSM 11999.The results show that,respectively with potato starch and peptone as the car bon source and the nitrogen source,and with the addition of MnCl₄,EDTA-Fe-Na,K₂HPO₄ ,ZnCl₂,CuSO₄ and growth factor alanine,epothilone can be produced via the fermentation of Sorangium cellulosum DSM1 1999 in the late exponential phase at 25 oC ．with a yield increased by 22.5% .

Key words: Sorangium cellulosum, ferm entation, epothilone, optimization

Luo Li-xin Wang Wei Lu Yi-ming Pan Li Sa Si-lin Kong Jun-wen. Optimized Conditions for Producing Epothilone via Fermentation of Sorangium cellulosum[J]. Journal of South China University of Technology (Natural Science Edition), 2006, 34(5): 48-52.

[1]	LU Zhimin, LI Bohang, TANG Wen, et al. Optimization Simulation of Ammonia Injection in SCR DeNO _x System of Coal-Fired Power Plant [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(8): 62-70.
[2]	WANG Xuewu, FANG Junyu, GAO Jin, et al. Multi-Objective Optimization Based on Improved Distribution of Solutions [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(8): 137-148.
[3]	HUANG Yan, FU Xinsha, ZENG Yanjie, et al. 3D Modeling Method of Highway Based on Lidar Odometer [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(7): 129-138.
[4]	WEI Haibin, WEI Dongsheng, JIANG Boyu, et al. Prediction Analysis of Settlement of Existing Road Under Shield Tunneling Based on IPSO-SVR [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(6): 62-71.
[5]	ZHAO Qiang, LIU Chuanwei, ZHANG Na, et al. Active Disturbance Rejection Control of Active Stabilizer System Based on Particle Swarm Optimization [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(6): 52-61.
[6]	QIU Yudong, WANG Zhan, XIE Zhishen. Optimization for Steel Frames with Semirigid Connections Based on Hybrid Algorithms [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(6): 72-77.
[7]	HAN Le, JIANG Yihua. Robust TruncatedL1-L2Total Variation Sparse Restoration Models [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(5): 45-53,140.
[8]	LI Shuxun, HU Yinggang, LI Cheng, et al. Optimization of Body Profile Line of Axial Flow Control Valve Based on Surrogate Model [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(3): 41-52.
[9]	WEN Shangsheng, QIU Zhiqiang, XU Hanming, et al. Self-Reset Particle Filter Method Optimized Based on Differential Evolution Algorithm [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(3): 133-145.
[10]	LI Xinkai, HU Xiaocheng, MA Ping, et al. Unmanned obstacle avoidance and tracking control based on improved DDPG [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(11): 44-55.
[11]	JIANG Yu, WANG Yasha, XUE Qingwen, et al. Research on Space-Time Taxiing Optimization of Aircraft Based on Carbon Emission [J]. Journal of South China University of Technology(Natural Science Edition), 2023, 51(10): 152-159.
[12]	NIE Jiamei, HUANG Xiaorong, ZHANG Xiaoliang, et al. Network Synthesis Design Method of Nonlinear Mem-inerter Suspension System [J]. Journal of South China University of Technology(Natural Science Edition), 2022, 50(9): 78-89.
[13]	ZHAO Kegang, HE Kunyang, LI Jie, et al. Multi-objective Energy Management Strategy of HEV Based on Improved Dynamic Programming Method [J]. Journal of South China University of Technology(Natural Science Edition), 2022, 50(9): 138-148.
[14]	WENG Jiancheng, WANG Maolin, LIN Pengfei, et al. Cross-line Combined Bus Scheduling Optimization Method Based on Passenger Flow Characteristic Identification [J]. Journal of South China University of Technology(Natural Science Edition), 2022, 50(9): 39-48.
[15]	XU Xilin, ZHAO Sibo, ZHENG Liuqing, et al. Culture Medium Optimization and Probiotic Characteristics Evaluation of Lactobacillus rhamnosus LR-ZB1107-01 [J]. Journal of South China University of Technology(Natural Science Edition), 2022, 50(8): 21-29.

Optimized Conditions for Producing Epothilone via Fermentation of Sorangium cellulosum

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments