华南理工大学学报(自然科学版)

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增材制造钛合金在骨科应用中的最新研究进展

张云龙1  王兆彬1  张唯一1  葛奕呈1  任晓雪2  王伟娥3  李成海1  翟梓棫1  刘德宝1  杨慧1   

  1. 1.佳木斯大学 材料科学与工程学院,黑龙江 佳木斯 154007

    2.黑龙江农业工程学院 机械工程学院,黑龙江 哈尔滨 150036

    3.佳木斯大学 药学院,黑龙江 佳木斯 154007

  • 发布日期:2026-01-23

The Latest Research Progress of Additive Manufacturing Titanium Alloys in Orthopedic Applications

ZHANG Yunlong1  WANG Zhaobin1  ZHANG Weiyi1  GE Yicheng1  REN Xiaoxue2  WANG Wei'e3  LI Chenghai1  ZHAI Ziyu1  LIU Debao1  YANG Hui1   

  1. 1. Collage of Materials Science and Engineering, Jiamusi University, Jiamusi 154007, Heilongjiang, China;

    2. Collage of Mechanical Engineering, Heilongjiang Agricultural Engineering College, Harbin 150036, Heilongjiang, China;

    3. Collage of Pharmacy, Jiamusi University, Jiamusi 154007, Heilongjiang, China

  • Published:2026-01-23

摘要:

钛合金因兼具高比强度、低弹性模量、优异的生物相容性与自发钝化形成的稳定氧化膜,在骨科植入物中长期占据重要地位,是临床使用最成熟的金属材料之一。由于传统减材加工难以同步实现拓扑优化、梯度孔隙与个体化定制相匹配,增材制造(AM)技术的出现将为上述瓶颈问题提供了系统性解决方案。选择性激光熔化(SLM)与电子束熔化(EBM)作为粉末床熔融(PBF)路线的典型代表,通过高能束逐层熔化Ti-6Al-4V预合金粉末,可在介观尺度精确调控相结构,将压缩弹性模量从传统轧制态的110GPa降至与皮质骨水平(≈17GPa)相接近。本文综述了钛合金在弹性模量调控、多孔结构设计、生物活性增强以及耐腐蚀性提升等方面的最新研究进展,并探讨SLM与EBM两种技术在成型精度、力学性能与生物行为上的差异与优势,同时还分析了增材制造钛合金在髋关节置换、椎间融合器与下颌骨重建等典型骨科临床应用中的临床案例。增材制造钛合金,通过跨尺度力学适配、表面生物活化及精准结构重建,正推动骨科植入物由“标准化”向“个体功能化”范式跃迁,未来需进一步解决打印缺陷无损评价、长期生物学响应等关键科学问题。

关键词: 增材制造, 钛合金, 骨科应用, 性能特点

Abstract:

Titanium alloys have long been regarded as the "gold standard" in the field of orthopedic implants due to their high specific strength, low elastic modulus, excellent biocompatibility and the stable oxide film formed by spontaneous passivation. However, traditional subtractive processing is difficult to simultaneously achieve topological optimization, gradient porosity and individualized anatomical matching. The emergence of additive manufacturing (AM) technology provides a systematic solution to the above bottleneck problems. Selective laser melting (SLM) and electron beam melting (EBM), as typical representatives of the powder bed melting (PBF) route, can precisely control the phase structure at the mesoscopic scale by melting the Ti-6Al-4V pre-alloyed powder layer by layer with a high-energy beam. The compressive elastic modulus is reduced from 110GPa in the traditional rolled state to be close to the cortical bone level (≈17GPa). This thesis reviews the latest research progress of titanium alloys in terms of elastic modulus regulation, porous structure design, enhanced biological activity and improved corrosion resistance. Then it discusses the differences and advantages of SLM and EBM technologies in forming accuracy, mechanical properties and biological behavior. At the same time, clinical cases of additively manufactured titanium alloys in typical orthopedic clinical applications such as hip replacement, intervertebral fusion devices and mandibular reconstruction are also analyzed. Additive manufacturing of titanium alloys is driving the transformation of orthopedic implants from the "standardization" paradigm to the "individual functionalization" paradigm through cross-scale mechanical adaptation, surface biological activation and precise structure reconstruction. In the future, key scientific issues such as non-destructive evaluation of printing defects, long-term biological response need to be further addressed.

Key words: additive manufacturing, titanium alloy, orthopedic application, performance characteristic