Journal of South China University of Technology (Natural Science Edition) ›› 2009, Vol. 37 ›› Issue (7): 132-134.

• Physics • Previous Articles     Next Articles

Effects of Additive and Multiplicative Noises on Gene Transcription Regulation

Liu Xue-mei  Wen De-hua  Xie Hui-zhang  Gao Ya-ni   

  1. Department of Physics, South China University of Technology, Guangzhou 5106.10, Guangdong, China
  • Received:2008-05-27 Revised:2008-10-14 Online:2009-07-25 Published:2009-07-25
  • Contact: 刘雪梅（1975-），女，讲师，博士，主要从事生物物理研究． E-mail:liuxm@scut．edu．cn
  • About author:刘雪梅（1975-），女，讲师，博士，主要从事生物物理研究．
  • Supported by:

    中国博士后基金特别资助项目（200801251）

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Abstract:

More and more biological experiments and is a nonlinearly stochastic process, in which the noise theoretical simulations have re,revealed that the gene expression can not be ignored. In this paper, additive and multiplicative noises are introduced in the kinetic model of activator proposed by Smolen for gene transcription regulation, and the corresponding Langevin and Fokker-Planck equations are solved to analyze the steady-state probability distribution theoretically and numerically. It is found that multiplicative noise significantly affects the steady-state probability distribution and converts the hi-stability to the monostabillity, and that additive noise helps to reduce the transcription efficiency.

Key words: gene transcription, noise, steady-state probability distribution, switching mechanism