Journal of South China University of Technology (Natural Science Edition) ›› 2006, Vol. 34 ›› Issue (8): 116-120.

• Food Science & Technology • Previous Articles     Next Articles

Anti-Aging and Immune Regulation Efects of Peptides Derived from Big-Head Carp(Aristichthys nobilis)Protein

Li Lin1  Zhao Mou-ming1  Wang Wei1  Wu Min-zhi2  Xie Guo2   

  1. 1.School of Light Industry and Food Sciences,South China Univ.of Tech.,Guangzhou 5 10640,Guangdong,China;2.Zhongshan College,Univ.of Electronic Science and Tech.of China,Zhongshan 528402,Guangdong,China
  • Received:2005-09-08 Online:2006-08-25 Published:2006-08-25
  • Contact: 赵谋明，教授，E．mail：femmzhao@scut．edu．cn E-mail:lilinxiao man@163.corn
  • About author:李琳(1975-)，女，讲师，博士生，主要从事食品生物技术的研究
  • Supported by:

    广州市科技攻关项目(2004Zl-E0061)；中山市科技局资助项目(2004A055)

PDF

899

Abstract:

The a6ng mice models were induced by D-galactose(D-gal)to reveal the anti-aging effect of the pep.tides derived from big-head carp protein on the index of immune apparatus and the phagocytic functions of phago-cytes as well as on the content of malonadehide(MDA),the activities of superoxide dimutase(SOD),glutathi-one peroxidase(GSH-Px)and monoamine oxidase-B(MAO-B)in the liver,brain and blood serum of mice.The activities of Ca2+ -Mg2+ -ATPase and Na+ -K+ -ATPase in myocardial mitochondria were also determined.The re-suhs indicate that the peptides derived from big-head carp protein can greatly decrease the MDA content in mice liver and brain and the activities of MAO-B in mice brain(P<0.01),increase the activities of anti-oxidative enzymes SOD and GSH-Px,and significantly afect the activities of Ca2+ -Mg2+ -ATPase and Na+ -K+-ATPase in mvo-cardial mitochondria.Moreover,the peptides can also enhance the phagocytic functions of phagocytes in aging mice (P<0.01).All these imply obvious anti-aging and immune regulation effects of the peptides on the senile mice in-duced by D-gal.

Key words: big-head carp, peptide, anti-aging effect, immune regu lation