The cement industry is a high energy consuming industry, and the use of mineralizers in the calcination process of cement clinker is an effective energy-saving method. Using solid waste as a mineralizer can also turn waste into treasure and achieve its resource utilization. With pyrite tailings as mineralizer, this study prepared Portland cement clinker with 0, 1.5%, 2.0% and 2.5% SO3 at calcination temperature of 1 350 ℃, 1 400 ℃ and 1 450 ℃. Thermal analysis, X-ray diffraction (XRD), polarizing microscope, and other methods were used to analyze the effects of SO3 addition on the calcination process, mineral composition, petrographic structure, and physical properties of the clinker. The results show that the best effect is achieved when the content of SO3 is 2.0%. Under this proportion, the content of f-CaO in cement clinker decreases from 1.84% to 1.18%, which can significantly improve the burnability of raw meal. The addition of pyrite tailings can reduce the initial and peak temperatures of CaCO3 decomposition in raw meal, and form two transition phases of calcium sulphosilicate (2C2S·CaSO4) and calcium sulphoaluminate (4CaO·3Al2O3·SO3) at low temperature. This reduces the temperature of liquid phase by 35 ℃, promoting the formation and development of clinker minerals, and has a significant mineralization effect. The cement clinker obtained by calcination with pyrite tailings has good performance, and its compressive strength after curing for 3 days and 28 days is 33.1 and 61.8 MPa, respectively.