Journal of South China University of Technology(Natural Science Edition) ›› 2012, Vol. 40 ›› Issue (12): 151-156.

• Biological Engineering • Previous Articles    

Effects of Aqueous Extract from Salvia miltiorrhiza Bunge on Serum Lipid Level and Liver in Ovariectomized Rats

Li Chun-mei1  Yang Ri-fu1  Gu Qu-liang2  Wang Bo3  Wu Jian-hong3  Fan Xiao-dan1  Chan Shun-wan3,4  Qiu Tai-qiu1  Wong Man-sau3,4   

  1. 1. School of Light Industry and Food Sciences,South China University of Technology,Guangzhou 510640,Guangdong,China; 2. School of Basic Courses,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China; 3. State Key Laboratory of Chinese Medicine and Molecular Pharmacology,Shenzhen 518057,Guangdong,China; 4. Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong 999077,China
  • Received:2012-04-06 Revised:2012-07-06 Online:2012-12-25 Published:2012-11-02
  • Contact: 丘泰球(1941-) ，男，教授，博士生导师，主要从事中药活性物质的提取及纯化研究． E-mail: tqqiu@scut．edu．cn E-mail:pianpain2@yahoo.com.cn
  • About author:李春梅(1977-) ，女，博士生，广东药学院讲师，主要从事生化药理研究．
  • Supported by:

    国家自然科学基金资助项目( 20776047) ; 国家“十一五”科技支撑计划重点项目( 2006BAD27B03) ; 广东省科技计划项目( 2009A030100007) ; 华南理工大学中央高校基本科研业务费资助项目( 2011ZM0093)

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Abstract:

In order to evaluate the estrogenic effect of Salvia miltiorrhiza Bunge ( SM) ,32 six-month-old female SD rats were randomly divided into 4 groups,namely,sham-operated rats + vehicle ( marked as Sham) ,ovariectomized rats + vehicle ( marked as OVX) ,ovariectomized rats + 17 β-estradiol ( 1mg·kg -1·d -1,p. o. ,marked as E2) ,ovariectomized rats + SM ( 600 mg·kg -1·d -1,p. o. ,marked as SM) . After the treatment for 12 weeks,the body weight gain,uterus weight index,serum lipid level,serum transaminase activity and oxidant / antioxidant level were detected,and a histological examination of the liver was carried out. The results show that the treatment with aqueous extract for 12 weeks helps to reduce the body weight gain,stimulate the growth of the atrophic uterus,improve the serum lipid level,decrease the ALT and AST levels in serum and suppress the lipid
accumulation in the liver of ovariectomized rats. All these above-mentioned protective effects of SM extract probably relate to the inhibition of oxidant ( Methane Dicarboxylic Aldehyde) level and the activity improvement of antioxidant enzymes such as super oxygen dehydrogenises,catalase and glutathione peroxidase.

Key words: Salvia miltiorrhiza Bunge, aqueous extract, ovariectomized rat, serum lipid, liver

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