Journal of South China University of Technology (Natural Science Edition) ›› 2021, Vol. 49 ›› Issue (9): 11-21.doi: 10.12141/j.issn.1000-565X.200367

Special Issue: 2021年食品科学与技术

• Food Science & Technology • Previous Articles     Next Articles

Safety and Potential Functional Characteristics of Bacillus coagulans 13002

LIU Dongmei ZHAO Shan ZHOU Qinyu HUANG Yanyan NAN Shugang   

  1. School of Food Science and Engineering，South China University of Technology，Guangzhou 510640，Guangdong，China
  • Received:2020-06-28 Revised:2020-09-04 Online:2021-09-25 Published:2021-09-01
  • Contact: 刘冬梅（1971-），女，博士，教授，主要从事食品微生物的利用与控制研究。 E-mail:liudm@scut.edu.cn
  • About author:刘冬梅（1971-），女，博士，教授，主要从事食品微生物的利用与控制研究。
  • Supported by:
    Supported by the National Natural Science Foundation of China (31771908) and the Science and Technology Planning Project of Guangdong Province (2013B020312002)

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Abstract: In this study，the acute toxicological safety，prebiotic in vitro and functional characteristics in vivo of Bacillus coagulans 13002 were evaluated.The results show that Bacillus coagulans 13002 is non-toxic，which acutely oral for female and male KM mice，and that it possesses good tolerance to simulated gastrointestinal digestion fluid.Moreover，it is resistant to Staphylococcus aureus ATCC 12598 （G+） and Escherichia coli ATCC 25922 （G-），which can obviously destroy the microstructure.These results indicate that the combination of Bacillus coagulans 13002 with fructooligosaccharide has a certain recovery effect on cyclophosphamide-induced tissue damage in mice，which can increase blood cells，improve protein synthesis rate and glucose utilization，and remove excess cholesterol to maintain the health of mice.

Key words: Bacillus coagulans, safety, functional characteristics

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