Journal of South China University of Technology(Natural Science Edition) ›› 2012, Vol. 40 ›› Issue (7): 142-147.

• Materials Science & Technology • Previous Articles     Next Articles

Purification of Sodium Alginate and Preparation of Porous Calcium Alginate Scaffolds

Liu Yang  Ren Li  Ji Pei-hong  Wang Ying-jun   

  1. School of Materials Science and Engineering∥National Engineering Research Center for Tissue Restoration and Reconstruction∥Guangdong Province Key Laboratory of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China
  • Received:2012-02-11 Revised:2012-04-10 Online:2012-07-25 Published:2012-06-01
  • Contact: 任力(1973-) ，男，教授，博士生导师，主要从事生物医用材料和组织工程研究． E-mail: psliren@scut．edu．cn E-mail:liuyang_cug@ yahoo.com.cn
  • About author:刘杨(1985-) ，男，博士生，主要从事高分子材料、生物医用材料研究．
  • Supported by:

    国家自然科学基金重点项目( 50732003; 50803018)

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Abstract:

Sodium alginate ( AlgNa) was purified via the acetone precipitation,and the product was tested by means of FT-IR and GPC. Then,the contants of residual protein in both the unpurified and the purified samples were measured,and several three-dimension porous calcium alginate scaffolds were fabricated through such three crosslinking systems as CaCl2-AlgNa,CaSO4 /GDL-AlgNa and Ca-EDTA/GDL-AlgNa. The results indicate that the
porous Ca-EDTA/GDL-AlgNa scaffold with a sodium alginate content of 2.5%～ 3.0% possesses uniform micropore distribution,large specific surface area and excellent mechanical behavior,which means that it is suitable for the cell culture in tissue engineering and cell engineering.

Key words: tissue engineering, porous scaffold, calcium alginate, sodium alginate

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