Journal of South China University of Technology (Natural Science Edition) ›› 2006, Vol. 34 ›› Issue (3): 58-62.

• Chemistry,Chemical & Energy Engineering • Previous Articles     Next Articles

Antibacterial Activities of Chitosans with Diferent Degrees of Deacetylation and M olecular M asse

Wu Xiao-yong  zeng Qing-xiao  Mo Shao-fang  Ruan Zhen   

  1. College of Light Chemistry and Food Science，South China Univ．of Tech．，Guangzhou 510640，Guangdong，China
  • Received:2004-09-13 Online:2006-03-25 Published:2006-03-25
  • Contact: Wu Xiao-yong(bom in 1972,male,Ph.D.candidate，mainly researches on the preparation and applicationof chitosan E-mail:perryfe@163.com
  • About author:Wu Xiao-yong(bom in 1972,male,Ph.D.candidate，mainly researches on the preparation and applicationof chitosan
  • Supported by:

    Supposed by the Key Agriculture R&D Program of Guangdong Province(2002C203 14)

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Abstract:

Abstract:Chitosans with different Degrees of Deacetylation(DDs)or diferent Molecular Masses(MMs)were prepared.The antibacterial activities of the prepared chitosans against Staphylococcus aureus (S.aureus).Escherichia coli(E.coli),Bacillus subtilis(B.subtilis)and Pseudomonas fluore,cens(P.fluorescenss ) were then determined and compared by measuring the MIC(Minimum Inhibitory Concentration).Results indicate that the antibacterial activities of chitosans with the same DD increasc with their MMs ranging from 400 to 800ku,that chitosans with different DDs(68.4%,75.3%,83.6% and 93.7%)but approximate MM (about 430 ku)possess almost the same antibacterial activity,that chitosan has the hiighest antibacterial activity at the pH value of about 5.5 to 6.0，that the growth of S.aureus can be easily inhibited by chitosan,while E coli is the bacterium that is most dificult to inhibit in the experiment,and that,generally,all tested chitosans have strong antibacterial activity against the four bacteria,which is higher than that of sodium benzoate (C7H5O2Na).

Key words: chitosan, antibacterial activity, degree of deacetylation, molecular mass