In order to study the high temperature and deformation resistance of laser cladding coating on TC4 surface, different proportions of nickel-metal-multi-ceramic composite coatings were prepared on TC4 matrix by laser cladding technology. And GH4169 nickel-based superalloy powder was taken as the base powder, HfC, ZrC, TaC and NbC transition carbides as the reinforcing phase. The microstructure, hardness and high temperature deformation resistance of coatings with different multi-component ceramic powder contents were systematically studied by microstructure characterization and performance experiments. The results show that the addition of carbide ceramic reinforcement phase refines the microstructure of the coating and improves the hardness, and the hardness is the highest when the proportion of ceramic reinforcement phase is 15%, which is 2.54 times that of the substrate. With the increase of temperature, the internal dendrites of the pure nickel-based cladding coating were dissolved and separated, and gradually isoaxed. The dendrite fragmentation appeared in the nickel-based cladding coating supplemented with 15% ceramic powder, and the ceramic strengthened phase dispersed in the cladding layer gathered and grew. Under the conditions of three temperature compression test temperatures (700, 800 and 900 ℃), the maximum equivalent stress and maximum equivalent strain of the specimen appear in the matrix, and compared with the TC4 specimen, the laser cladding specimen produces a stress abrupt change in the coating bonding zone, and the deformation resistance ability of the laser cladding specimen coating is enhanced.