Tactile sensors have received extensive attention and research because they can imitate human skin to perceive external information.Among varies kinds of tactile sensor，Nano-ZnO-based tactile sensor has broad application prospects in the fields of bionic robots，human-computer interaction，biomedicine devices and wearable electronic systems due to its advantages of high sensitivity，high mechanical strength，strong flexibility，easy integration，good biocompatibility，and low-cost technology.This paper firstly introduced the piezoelectric mechanism and the manufacturing of Nano-ZnO-based tactile sensor.Next，it summarized the study progress of Nano-ZnO piezoelectric tactile sensor from the four aspects of piezoelectric performance improvement，multi-function，integration，and array fabrication，and listed the latest achievements in related technical fields and research directions.Then it summarized the application research of Nano-ZnO piezoelectric tactile sensor in pressure imaging，human action detection and physiological health monitoring in detail，and analyzed the shortcomings and the research trend of Nano-ZnO piezoelectric tactile sensor.