Dental caries is closely related to dental plaque，a biofilm in which bacteria attach to the teeth surface．This paper deals with the feasibility of eliminating dental plague by using a kind of mouthwash in which combined enzymes are used to degrade glucan and starch． In the investigation，the Tureskey modified Q-H indexes of 20 vo-lunteers were measured to compare the elimination effect of the enzyme-combined mouthwash，the mouthwash with-out enzymes and the commercially available mouthwash with essential oil． Statistical results indicate that，when the enzyme content is higher than 0. 5mg/L，the mouthwash containing β-glucanase and α-amylase is more effec-tive than the one without enzymes; and that，when the enzyme content is higher than 5. 0mg/L，the enzyme-com-bined mouthwash presents a dental plague elimination rate higher than that of the commercially available mouth-wash． It is thus concluded that the mouthwash with combined enzymes is effective in eliminating dental plague．This research lays a theoretical foundation for developing products for the daily prevention of dental caries．