Journal of South China University of Technology (Natural Science Edition) ›› 2013, Vol. 41 ›› Issue (7): 62-67.doi: 10.3969/j.issn.1000-565X.2013.07.011

• Chemistry & Chemical Engineering • Previous Articles     Next Articles

Preparation and Characterization of Photo- Crosslinked N- Acryloyl- Glucosamine/Poly(Ethylene Glycol) Diacrylate Hydrogels

Wang Qun- fang Ren Li Wang Ying- jun Yao Yong- chang Hou Si- run   

  1. School of Materials Science and Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China∥National Engineering Research Center for Tissue Restoration and Reconstruction,Guangzhou 510006,Guangdong,China
  • Received:2013-03-15 Online:2013-07-25 Published:2013-06-01
  • Contact: 王迎军(1954-)，女，教授，博士生导师，主要从事生物医用材料研究． E-mail:imwangyj@163.com
  • About author:王群芳(1971-)，女，博士生，高级工程师，主要从事生物医用材料研究．E-mail:wang3525@126．com
  • Supported by:

    国家 “973” 计划项目(2012CB619100);国家自然科学基金资助项目(51232002， 51273072)

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Abstract:

 N-acryloyl- glucosamine (AGA) and poly(ethylene glycol) diacrylate (PEGDA) were used to prepare hydrogels via an in- situ forming procedure with photopolymerization,and1 H NMR was employed to reveal the com-position variation of AGA/PEGDA system during the gelation.Then,the chemical composition and morphology of lyophilized hydrogels were evaluated by means of FT- IR,XPS and SEM,and the effects of photoinitiator mass con-centration,AGA dosage and PEGDA dosage on the swelling ratio and the crosslinking yield were investigated.The results indicate that glucosamine is successfully incorporated into PEGDA hydrogel network,that the crosslinking yield reaches the maximum at a photoinitiator content of 0.6g/L,that the crosslinking yield of hydrogels decreases with the increase of AGA dosage but decreases first and then increases with the increase of PEGDA dosage,that the swelling ratio of hydrogels decreases with the increase of AGA and PEGDA dosages,and that a shrinking surface may occur at high AGA dosage.

Key words: glucosamine, poly(ethylene glycol) diacrylate, photopolymerization, in- situ forming, hydrogel