Journal of South China University of Technology (Natural Science Edition) ›› 2014, Vol. 42 ›› Issue (2): 44-49,56.doi: 10.3969/j.issn.1000-565X.2014.02.008

• Chemistry & Chemical Engineering • Previous Articles     Next Articles

Certification of Dienestrol Purity Reference Material and Its Uncertainty Evaluation

Jiang Feng1 Wang Zhi- long2 Wang Qiao- yun2 Shen Yu- xing2   

  1. 1.School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China;2.Guangzhou Institute of Measurement Testing Technology,Guangzhou 510030,Guangdong,China
  • Received:2013-07-04 Revised:2013-12-05 Online:2014-02-25 Published:2014-01-02
  • Contact: 姜峰(1980-)，男，博士，广州计量检测技术研究院工程师，主要从事标准物质及化学计量检测研究． E-mail:chemjiangf@163.com
  • About author:姜峰(1980-)，男，博士，广州计量检测技术研究院工程师，主要从事标准物质及化学计量检测研究．
  • Supported by:

    国家质检总局科技计划项目(2011QK313);广东省质量技术监督局科技项目(2011CJ01)

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Abstract:

In this paper,first,certified reference material (CRM) for the purity determination of dienestrol wasprepared by means of semi- preparative high- performance liquid chromatography. Next,a qualitative analysis of theraw materials was performed by using liquid chromatography- mass spectrometry,1H NMR,13C NMR and infraredspectroscopy.Then,the content of organic main ingredients in the prepared CRM was determined via the multi- labcertification with HPLC,and the homogeneity and stability of the CRM were measured. Moreover, the contents ofwater,ash,volatile materials and inorganic elements were analyzed,with an uncertainty evaluation of the CRM be-ing finally carried out.The results indicate that (1) the prepared CRM possesses good homogeneity and is of a sta-ble storage period of 12 months; (2) the contents of water,ash,volatile materials and inorganic elements in theprepared CRM of dienestrol are all less than 0.1%; and (3) the prepared CRM is of a certified purity of 99.4%and a relative expanded uncertainty of 0.6% (k =2).

Key words: dienestrol, certified reference material, high- performance liquid chromatography, certification, uncer-tainty