Journal of South China University of Technology (Natural Science Edition) ›› 2008, Vol. 36 ›› Issue (3): 60-63.

• Chemistry & Chemical Engineering • Previous Articles     Next Articles

Synthesis and Fungicidal Activity of 4-Aryl-2-Benzyliminothiazole

He Dao-hang1  Ma Ying-qi1  Hu Ai-xi2  Xia Lin2  Ou Xiao-ming3   

  1. 1.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China; 2. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, Hunan, China; 3 National Engineering Research Center for Agrochemicals, Changsha 410007, Hunan, China
  • Received:2007-09-21 Online:2008-03-25 Published:2008-03-25
  • Contact: 胡艾希（1957-），男，教授，博士生导师． E-mail:axhu0731@yahoo．com．cn
  • About author:何道航（1973-），男，博士，助理研究员，主要从事生物活性天然产物及农药化学研究．E-mail：cehdh@scut．edu．cn
  • Supported by:

    国家科技支撑计划项目（2006BAE01A01-4）

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Abstract:

4-arylthiazol-2-amines were synthesized by the reaction of a-bromoarylalkyl ketone with thiourea, and further reacted with salicylal to give nine 4-aryl-2-benzyliminothiazoles. The structures of all new compounds were confirmed by 1 NMR spectra. The results of preliminary bioassay show that the title compound （E）-2-（（4-（3-（triiquoromethyl） phenyl） thiazol-2-ylimino）methyl） phenol exhibits an inhibition rate of 60.0 % against Rhizoctonia solani at a concentration of 500 mg/L and that the inhibition rates of compounds （E）-1-（2-chloro-4-（4-chlorophe-noxy）phenyl）-2-（2-（2-hydroxybenzylideneamino） thiazol-4-yl） ethanone and （E）-2-（（4-（3-chlorophenyl） thiazol-2-ylimino） methyl） phenol against Sclerotinia sclerotiorum are 65.4% and 56.1%, respectively.

Key words: 4-aryl-2-benzyliminothiazole, synthesis, fungicidal activity