Journal of South China University of Technology (Natural Science Edition) ›› 2007, Vol. 35 ›› Issue (10): 99-104.

• Electronics, Communication & Automation Technology • Previous Articles     Next Articles

Biomimetic Preparation of the Composite for Bone Restoration and Mineralization Modulated by the Biomolecules

Wang Ying-jun  Chen Xiao-feng  Yang Chun-rong  Deng Chun-lin  Zhao Na-ru   

  1. Key Laboratory of Specially Functional Materials of the Ministry of Education , South China Univ. of Tech. ,Guangzhou 510640 , Gllangdong , China
  • Received:2007-03-26 Online:2007-10-25 Published:2007-10-25
  • Contact: 王迎军(1954-) ，女，教授，博士生导师，主要从事生物医学材料、高性能陶瓷和复合材料的研究. E-mail:imwangyj@ scut. edu. cn
  • About author:王迎军(1954-) ，女，教授，博士生导师，主要从事生物医学材料、高性能陶瓷和复合材料的研究.
  • Supported by:

    国家973 项目(2005CB623902) ;国家自然科学基金资助项目(50472054 ， 50672028) ;教育部重大科技项目(教计司[2005 ]4 号) ;广东省自然科学团队基金资助项目(4205786)

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Abstract:

BG-COL-HYA-PS porous composite for bone restoration was prepared via the biomimetic method using refrigeration-desiccation and nano-synthesis techniques The mechanism of bio-mineralization and biomolecular modulation of the composite in the simulated body fluid , in the cell culture fluid and in vivo , were respectively investigated by means of the techniques such as biomimetic mineralization in vitro , bioassembly , implantation to animals ,histological morphology observation , SEM/EDS and XRD. The results indicate that the natural extracellular matrixes such as collagen (COL) , hyaluronic acid (HYA) and phosphoserine (PS) play important roles in the modulation of mineralization. The prepared composite could effectively promote the new bone restoration.

Key words: bone restoration, bioglass, biomimetic preparation, bio-mineralization, modulation