Abstract:

The emulsion-congealing method was adopted to prepare ibuprofen-loaded solid lipid microparticles (SLM)with tristearin as the carrier.The stabilities of the SLM stabilized with different stabilizers were also investi.gated,proving that polyvinyl alcohol(PVA)and soy lecithin/bile salt are good stabilizers for the SLM system.Thestabilities of the SLM stabilized with these two stabilizers at an increasing ibuprofen content were then investigated.Experimental results show that.at an ibuprofen mass fraction of 7%,the SLM system stab ilized with soy lecithin/bile salt begins to congregate,while the one stabilized with PVA remains stab le even when ibuprofen mass fractionis up to 25% .The stabilizing mechanism of the stab ilizers was finally interpreted based on the analysis and simula-tion of the molecular structure of the stabilizer and the microstructure of the drug carrier.

Key words: solid lipid microparticle, stability, drug delivery system, ibuprofen