Journal of South China University of Technology (Natural Science Edition) ›› 2006, Vol. 34 ›› Issue (5): 63-67.

• Biological Engineering • Previous Articles     Next Articles

Efect of CpG DNA on CD4+ and CD8+ T Lymphocyte Subpopulations in Blood of Newborn Piglet

Zhang Ling-hua1  Guo Yong1  Tian Xing-shan2  Zhou Feng-zheng2   

  1. 1.College of Biological Science and Engineering,South China Univ.of Teeh.,Guangzhou 510640,Guangdong,China;2.Bio-Tech Research Institute,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,Guangdong,China
  • Received:2005-03-23 Online:2006-05-25 Published:2006-05-25
  • Contact: 张玲华(1973-)，女，副研究员，博士生，主要从事微生物工程与分子免疫学研究 E-mail:lhzhang7322000@yahoo.corn.cn
  • About author:张玲华(1973-)，女，副研究员，博士生，主要从事微生物工程与分子免疫学研究
  • Supported by:

    广州市科技攻关重点项目(2003Z2-E0221)；广东省农业攻关项目(2003B21403)

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Abstract:

The effect of immunostimulatory CpG 0lig0de0 ynucle0tides(CpG ODN)on CD4 and CD8 T lympho-cyte subpopulations in the blood of newborn piglets was investigated with or without pseudorabies attenuated(PSA) vaccine．Experimental results suggest that the CD4+ /CD8+ ratio decreases with the age of newbom pigs inoculated with the vaccine only，but keeps steady in pigs treated with CpG ODN and PSA vaccine(P>0．05)，that CpG ODN can effectively prevent the decrease in the proportion of CIM T cell caused by PSA vaccine，and that high titer of PSA specific antibody can be tested in the serum of newborn piglets immunized by both PSA vaccine and CpG ODN(P<0．05)．All these indicate that CpG ODN can greatly enhance the immune response of animals．

Key words: CpG, T lymphocyte, immune response, firstborn piglet, immune reinforcing agent, pseudorabies attenuated vaccin