Journal of South China University of Technology (Natural Science Edition) ›› 2020, Vol. 48 ›› Issue (4): 80-86.doi: 10.12141/j.issn.1000-565X.190588

• Chemistry & Chemical Engineering • Previous Articles     Next Articles

Synthesis and Antibacterial Property of IRMOF-3 Grafted with Citral

SU Jianyu1 GUAN Jingwei1 FANG Liming2 XU Zhenbo1 XIAO Yuxi1   

  1. 1． School of Food Science and Engineering，South China University of Technology，Guangzhou 510640，Guangdong，China;2． School of Materials Science and Engineering，South China University of Technology，Guangzhou 510640，Guangdong，China
  • Received:2019-09-11 Revised:2019-11-11 Online:2020-04-25 Published:2020-04-01
  • Contact: 方立明(1979-)，男，博士，副研究员，主要从事医用生物材料研究。 E-mail:lmfang@scut.edu.cn
  • About author:苏健裕(1979-)，男，博士，副研究员，主要从事食品生物技术研究。E-mail:jysu@scut.edu.cn
  • Supported by:
    Supported by the National 13th Five-Year Key Research and Development Plan (2017YFD0601303) and the Natural Science Foundation of Guangdong Province (2015A030312004)

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Abstract: There is an urgent need for novel antimicrobial alternatives due to the increasing drug resistant bacteria and the slow development of antibiotics． Citral is a natural broad-spectrum antibacterial agent with poor stability and applicability． Metal organic framework is a porous material synthesized from metal ions and organic building blocks with large specific surface area． The metal ions endow it with antibacterial property，and rich organic ligands allow it for easier functionalization． As a result，nano-sized metal organic framework particles (IRMOF-3) with amino groups were synthesized by zinc acetate method，and the particle surface was grafted with citral (IRMOF-3-C)．Fourier transform infrared spectroscopy and electrospray ionization mass spectrometry analysis indicates that citral and IRMOF-3 form a Schiff base bond with an acid responsibility． Antibacterial tests show that，as compared with citral and IRMOF-3，IRMOF-3-C can significantly improve the bacteriostatic and bactericidal properties against Escherichia coli and Staphylococcus aureus，and exhibits good antibacterial property and stability．

Key words: citral, metal-organic frameworks, antibacterial property, grafting

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