华南理工大学学报(自然科学版) ›› 2009, Vol. 37 ›› Issue (12): 100-104.

• 生物工程 • 上一篇    下一篇

新型心肺复苏术血流动力学效果的模型研究

张燕儒1  吴效明2  袁衡新3  徐林1   

  1. 1.华南理工大学 计算机科学与工程学院, 广东 广州 510006; 2.华南理工大学 生物科学与工程学院, 广东 广州 510006;3.中山大学 中山医学院, 广东 广州 510080
  • 收稿日期:2008-10-17 修回日期:2009-03-03 出版日期:2009-12-25 发布日期:2009-12-25
  • 通信作者: 张燕儒(1982-),女,博士生,主要从事计算机应用技术、血液循环系统建模研究. E-mail:yanruzhang2007@gmail.com
  • 作者简介:张燕儒(1982-),女,博士生,主要从事计算机应用技术、血液循环系统建模研究.
  • 基金资助:

    国家自然科学基金资助项目(30670538);广东自然科学基金资助项目(04020048)

Hemodynamic Effects of a New Cardiopulmonary Resuscitation: Study with Computer Model

Zhang Yan-ru Wu Xiao-ming2  Yuan Heng-xin3  Xu Lin1   

  1. 1. School of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China; 2. School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China; 3. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
  • Received:2008-10-17 Revised:2009-03-03 Online:2009-12-25 Published:2009-12-25
  • Contact: 张燕儒(1982-),女,博士生,主要从事计算机应用技术、血液循环系统建模研究. E-mail:yanruzhang2007@gmail.com
  • About author:张燕儒(1982-),女,博士生,主要从事计算机应用技术、血液循环系统建模研究.
  • Supported by:

    国家自然科学基金资助项目(30670538);广东自然科学基金资助项目(04020048)

摘要: 为实现新型复苏术——辅以增强型体外反搏和吸气阻力阀的主动按压放松心肺复苏术(AEI—CPR)的数字化,用计算机仿真模型模拟了人体在正常情况、心脏骤停以及采取新型复苏术后的血流动力学效果,并将标准复苏术(S—CPR)、主动按压复苏术(ACD—CPR)、以及带有增强型体外反搏的标准复苏术(SE.CPR)和新型复苏术AEI—CPR等的仿真结果进行了比较.结果表明:S—CPR产生的前向血流(FF)为1.1L/min,冠脉灌注压(CPP)为30.2mmHg;ACD—CPR产生的FF为1.2L/min,CPP为31.3mmHg;SE—CPR产生的FF为5.2L/min,CPP为57.4mmHg:AEI.CPR产生的FF为5.6L/min,CPP为57.6mmHg;带有增强型体外反搏的复苏术SE—CPR和AEI—CPR可显著提高前向血流,AEI—CPR的血流动力学效果最好.

关键词: 心肺复苏术, 数学模型, 增强型体外反搏, 前向血流, 冠脉灌注压

Abstract:

In order to digitalize a new cardiopulmonary resuscitation (CPR) called active compression-decompression CPR with enhanced external counterpulsation and inspiratory impedance threshold valve (AEI-CPR) , the hemodynamics of human body in the conditions of normal circulation, cardiac arrest and CPR were respectively simulated with computer model, and several CPR techniques, such as the standard CPR (S-CPR) , the active compres- sion-decompression CPR (ACD-CPR) , the standard CPR with enhanced external counterpulsation (SE-CPR) , and the AEI-CPR, were compared via simulation. The results indicate that (1) S-CPR generates a forward flow (FF) of 1.1 L/rain and a coronary perfusion pressure (CPP) of 30.2 mmHg, while those generated by ACD-CPR, SE- CPR and AEI-CPR are respectively 1.2 L/rain and 31.3 mmHg, 5.2 L/rain and 57.4 mmHg, and 5.6 L/rain and 57.6 mmHg ; (2) both the SE-CPR and the AEI-CPR greatly improve the forward flow ; and (3) AEI-CPR is of the best hemodynamic effect.

Key words: cardiopulmonary resuscitation, mathematical model, enhanced external counterpulsation, forward flow, coronary perfusion pressure