关键词: 基因转录, 噪声, 稳态概率分布, 开关机制

Abstract:

More and more biological experiments and is a nonlinearly stochastic process, in which the noise theoretical simulations have re,revealed that the gene expression can not be ignored. In this paper, additive and multiplicative noises are introduced in the kinetic model of activator proposed by Smolen for gene transcription regulation, and the corresponding Langevin and Fokker-Planck equations are solved to analyze the steady-state probability distribution theoretically and numerically. It is found that multiplicative noise significantly affects the steady-state probability distribution and converts the hi-stability to the monostabillity, and that additive noise helps to reduce the transcription efficiency.

Key words: gene transcription, noise, steady-state probability distribution, switching mechanism