关键词: 鳙鱼, 肽, 抗衰老作用, 免疫调节

Abstract:

The a6ng mice models were induced by D-galactose(D-gal)to reveal the anti-aging effect of the pep.tides derived from big-head carp protein on the index of immune apparatus and the phagocytic functions of phago-cytes as well as on the content of malonadehide(MDA),the activities of superoxide dimutase(SOD),glutathi-one peroxidase(GSH-Px)and monoamine oxidase-B(MAO-B)in the liver,brain and blood serum of mice.The activities of Ca²⁺ -Mg²⁺ -ATPase and Na⁺ -K⁺ -ATPase in myocardial mitochondria were also determined.The re-suhs indicate that the peptides derived from big-head carp protein can greatly decrease the MDA content in mice liver and brain and the activities of MAO-B in mice brain(P<0.01),increase the activities of anti-oxidative enzymes SOD and GSH-Px,and significantly afect the activities of Ca²⁺ -Mg²⁺ -ATPase and Na⁺ -K⁺-ATPase in mvo-cardial mitochondria.Moreover,the peptides can also enhance the phagocytic functions of phagocytes in aging mice (P<0.01).All these imply obvious anti-aging and immune regulation effects of the peptides on the senile mice in-duced by D-gal.

Key words: big-head carp, peptide, anti-aging effect, immune regu lation