华南理工大学学报(自然科学版) ›› 2011, Vol. 39 ›› Issue (10): 19-25,31.doi: 10.3969/j.issn.1000-565X.2011.10.004

• 电子、通信与自动控制 • 上一篇    下一篇

基于提升小波的神经元锋电位并行检测方法

祝晓平1 王东2 陈耀武1†   

  1. 1.浙江大学 生物医学工程与仪器科学学院,浙江 杭州 310027; 2.浙江大学 求是高等研究院,浙江 杭州 310027
  • 收稿日期:2011-04-12 修回日期:2011-05-19 出版日期:2011-10-25 发布日期:2011-09-01
  • 通信作者: 陈耀武(1963-) ,男,教授,博士生导师,主要从事智能技术与嵌入式系统、脑- 机接口信号处理与并行系统等的研究. E-mail: cyw@mail.bme.zju.edu.cn E-mail:zxp@ zju.edu.cn
  • 作者简介:祝晓平(1982-) ,男,博士生,主要从事脑-机接口信号处理与并行系统研究.
  • 基金资助:

    国家自然科学基金资助项目( 61031002) ; 浙江省自然科学基金资助项目( Y2090707) ; 浙江大学中央高校基本科研业务费专项资金资助项目( 2010QNA5026)

Parallel Detection Method of Neuronal Spikes Based on Lifting Wavelet

Zhu Xiao-pingWang DongChen Yao-wu1   

  1. 1. College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310027,Zhejiang,China; 2. Qiushi Academy for Advanced Studies,Zhejiang University,Hangzhou 310027,Zhejiang,China
  • Received:2011-04-12 Revised:2011-05-19 Online:2011-10-25 Published:2011-09-01
  • Contact: 陈耀武(1963-) ,男,教授,博士生导师,主要从事智能技术与嵌入式系统、脑- 机接口信号处理与并行系统等的研究. E-mail: cyw@mail.bme.zju.edu.cn E-mail:zxp@ zju.edu.cn
  • About author:祝晓平( 982-) ,男,博士生,主要从事脑-机接口信号处理与并行系统研究.
  • Supported by:

    国家自然科学基金资助项目( 61031002) ; 浙江省自然科学基金资助项目( Y2090707) ; 浙江大学中央高校基本科研业务费专项资金资助项目( 2010QNA5026)

摘要: 神经元动作电位( 即锋电位) 的实时检测是植入式脑- 机接口系统的重要组成环节,为了能够从多通道神经微电极阵列记录的神经信号中实时地检测并提取出神经元的锋电位信息,文中提出了基于提升小波的神经元锋电位检测方法.该方法采用提升小波方法去除了神经信号中的漂移和噪声,然后通过阈值法检测出锋电位信号,最后利用现场可编程门阵列( FPGA) 的并行性及流水线结构实现了多通道神经元锋电位的实时并行检测.实验结果显示: 和基于个人计算机的检测方法相比,在获得同样检测结果的情况下,文中方法的计算性能有很大的提升,且在单片FPGA 上可以实现40 个神经通道的并行处理; 文中方法不仅可以实现锋电位信号的实时并行检测,而且可以大大提高离线数据处理的效率.

关键词: 现场可编程门阵列, 锋电位检测, 多通道, 并行检测, 现场可编程门阵列, 提升小波, 多通道, 现场可编程门阵列, 锋电位检测, 并行检测, 提升小波, 多通道, 现场可编程门阵列

Abstract:

The real-time detection of neuronal action potentials ( namely spikes) plays an important role in the implantable brain-computer interface system. In order to implement the real-time detection and extraction of the neuronal spikes from the neural signals recorded by the real-time multi-channel neural microelectrode array,a detection method is proposed based on the lifting wavelet. In this method,the drift and noise of the neural signals are removed by using the lifting wavelet. Then,the neuronal spikes are detected via the threshold setting. Finally,the real-time parallel detection of the multi-channel neuronal spikes is realized by means of the lifting wavelet combining with the parallel and pipelined structures of FPGA. Experimental results show that,as compared with the personal computer-based detection method with the same detection results,the proposed method greatly improves the computational performance and it can achieve the parallel detection of 40 neural channels on a single FPGA chip,and that,the proposed method can not only achieve parallel real-time detection of neuronal spikes but also substantially increase the efficiency of the off-line data processing.

Key words: spike detection, parallel detection, lifting wavelet, multi-channel, field programmable gate array

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