In view of the influences of the wind direction and the horizontal fluctuating wind speed spectrum on the computational results of structural response,the complete quadratic combination( CQC) method is used to conduct the frequency domain analysis for the wind-induced vibration response of a practical long-span suspended dome roof structure,thus obtaining the wind vibration coefficients of the suspended dome in different wind directions. Then,the effect of the number of the vibration modes on the computational results of the structural response is investigated,and the computational results of the wind-induced vibration response for Davenport’s wind speed spectrum and other four spectrums are compared. The results of the analyses show that ( 1) the most sensitive wind directions of different parts of the structure are different,specifically,it is 45° for the center part of the structure and 0° for the remaining area except the cantilever part; ( 2) all parts of the structure are least sensitive to the wind direction of 90°; ( 3) the distribution of the wind-induced vibration coefficient of the internal force is more uniform than that of the displacement; and ( 4) the number of the vibration modes obviously affects the computational results of the practical structure response and it is,therefore,suggested to be more than 100. In addition,Harris’s wind speed spectrum is not suitable for the frequency domain analysis of the wind-induced vibration response of the long-span structure.