In this paper,the general situation of China National Pavilion at the Expo 2010 Shanghai China is introduced,the four tubes rising from the Regional Pavilion and connecting in the air being the exhibition hall with spreading layer upon layer,just like an inverse quadrangular frustum pyramid crown. Moreover,some characteristics of the structure design of the National Pavilion are expounded,which includes that so as to columns set based on the shape of the building vertically support the girders of floor inclined satisfy the demand of the big space service function without column within the exhibition hall,and by strengthening the stiffnesses of the coupling beam and the floor at 33. 3m elevation,the press of the floor is used to resist more horizontal component force from the inclined columns by means of self equilibrium rather than the shear of shear wall. Besides,the authors also introduce the structure layout at the elevations of 41. 4,49. 5,60. 3 and 69. 9 m,the joint configuration of connecting three inclined columns,the camber principle of composite beam,the measures in dealing with the girder with large internal force,seismic design,etc.