Journal of South China University of Technology(Natural Science) >

2024 , Vol. 52 >Issue 4: 17 - 25

DOI: https://doi.org/10.12141/j.issn.1000-565X.220815

Biological Engineering

Improvement Effects of Co-administration of Cartilage Extract, Turmeric Extract, Pueraria Lobata and Coix Seed Extract on Cartilage Damage of Rats with Knee Osteoarthritis

Expand
  • 1.School of Food Science and Engineering，South China University of Technology，Guangzhou 510640，Guangdong，China
    2.Infinitus （China） Company Ltd. ，Guangzhou 510665，Guangdong，China
    3.School of Pharmaceutical Science，Guangzhou University of Chinese Medicine，Guangzhou 510006，Guangdong，China
丁刘刚（1982-），男，博士生，主要从事食品生物技术研究。E-mail:109277322@qq.com

Received date: 2022-12-15

  Online published: 2023-10-25

Supported by

the Key Field R&D Program of Guangdong Province(2020B020226005)

Fold

Abstract

This paper studied the synergistic effects of turmeric extract, cartilage extract, Pueraria lobata and Coix (Coix lacryma-jobi) seed extract alone and the combination on the improvement of cartilage damage of rats with knee osteoarthritis. The synergistic effects of the three extracts in rat knee osteoarthritis were evaluated mainly by reducing knee swelling (inflammation), protecting chondrocyte and repairing joint cartilage. The results show that the turmeric extract has a more obvious effect in inhibiting joint swelling and improving cartilage damage, which is specifically manifested in the ability to better improve the levels of Collagen Ⅱ, matrix metalloproteinase 3 (MMP3), cartilage oligomeric matrix protein (COMP), tumor necrosis factor-alpha (TNF-α) and superoxide dismutase (SOD). The cartilage extract significantly improves the arthritic lesions by improving the levels of MMP3, COMP, TNF-α, prostaglandin E2 (PGE2) and SOD. Pueraria lobata and Coix seed extract improves the levels of Collagen Ⅱ and SOD, inhibits the elevation of MMP3, COMP, TNF-α and interleukin 1β (IL-1β), and improves cartilage damage of rats with knee osteoarthritis. The combined use of the three extracts exhibits better effects on the repair of rat knee cartilage. These data imply that by optimizing the ratio of turmeric extract, cartilage extract and Pueraria lobata and Coix seed extract, functional foods can be developed with significant anti-inflammatory and cartilage repairing effects and contribute to the realization of “Healthy China 2030”.

Key words： cartilage extract; turmeric exact; Pueraria lobata and Coix seed extract; knee osteoarthritis; cartilage repair

Cite this article

DING Liugang, GUAN Ting, MIAO Jindian, et al . Improvement Effects of Co-administration of Cartilage Extract, Turmeric Extract, Pueraria Lobata and Coix Seed Extract on Cartilage Damage of Rats with Knee Osteoarthritis[J]. Journal of South China University of Technology(Natural Science), 2024 , 52(4) : 17 -25 . DOI: 10.12141/j.issn.1000-565X.220815

References

1 ALTAY M A， ERTüRK C， BILGE A，et al ．Evaluation of prolidase activity and oxidative status in patients with knee osteoarthritis：relationships with radiographic severity and clinical parameters［J］．Rheumatology International，2015，35（10）：1725-1731.
2 GOLDRING M B， OTERO M ．Inflammation in osteoarthritis［J］．Current Opinion in Rheumatology，2011，23（5）：471-478.
3 VILá S ．Inflammation in osteoarthritis［J］．Puerto Rico Health Sciences Journal，2017，36（3）：123-129.
4 HéRAUD F， HéRAUD A， HARMAND M F ．Apoptosis in normal and osteoarthritic human articular cartilage［J］．Annals of the Rheumatic Diseases，2000，59（12）：959-965.
5 BISHNOI M， JAIN A， HURKAT P，et al ．Chondroitin sulphate：a focus on osteoarthritis［J］．Glycoconjugate Journal，2016，33（5）：693-705.
6 沈先月，李阳，张卓 ．姜黄素治疗骨关节炎的研究进展［J］．中华外科杂志，2021，59（6）：554-557.
  SHEN Xianyue， LI Yang， ZHANG Zhuo ．Research progress of curcumin in the treatment of osteoarthritis［J］．Chinese Journal of Surgery，2021，59（6）：554-557.
7 宋亚丽，公慧萍 ．姜黄素治疗骨关节炎的作用机制研究进展［J］．长治医学院学报，2021，35（6）：463-466.
  SONG Yali， GONG Huiping ．Progress on the mechanism of action of curcumin in the treatment of osteoarthritis［J］．Journal of Changzhi Medical College，2021，35（6）：463-466.
8 NAKAGAWA Y， MUKAI S， YAMADA S，et al ．The efficacy and safety of highly-bioavailable curcumin for treating knee osteoarthritis：a 6-month open-labeled prospective study［J］．Clinical Medicine Insights：Arthritis and Musculoskeletal Disorders，2020，13：1-8.
9 张春雷，李冀 ．膝骨关节炎的中医药治疗进展［J］．中医药学报，2022，50（1）：106-110.
  ZHANG Chunlei， LI Ji ．Progress in the treatment of osteoarthritis of the knee with traditional Chinese medicine［J］．Acta Chinese Medicine and Pharmacology，2022，50（1）：106-110.
10 HUANG X， PEI W， NI B，et al ．Chondroprotective and antiarthritic effects of galangin in osteoarthritis：an in vitro and in vivo study［J］．European Journal of Pharmacology，2021，906：174232/1-7.
11 SOHEL M J， TADASHI Y， MAKOTO S，et al ．Inhibition of interleukin-1β-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage［J］．Arthritis & Rheumatism，2004，50（2）：516-525.
12 BARANOVSKY D S， LYUNDUP A V， BALYASIN M V，et al ．Interleukin IL-1β stimulates cartilage scaffold revitalization in vitro with human nasal chondrocytes［J］．Russian Journal of Transplantology and Artificial Organs，2019，21（4）：88-95.
13 KOBAYASHI M， SQUIRES G R， MOUSA A，et al ．Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage［J］．Arthritis & Rheumatism，2005，52（1）：128-135.
14 苑文杰，宋锡国，徐翀，等 ．葛根素促进骨关节炎软骨细胞增殖和减轻氧化应激与炎性反应的机制研究［J］．母婴世界，2021（15）：77.
  YUAN Wenjie， SONG Xiguo， XU Chong ．Mechanism of Puerarin in promoting osteoarthritic chondrocyte proliferation and reducing oxidative stress and inflammatory response in osteoarthritis［J］．Super Baby，2021（15）：77.
15 温亚静 ．葛根素对ACLT诱导的骨关节炎模型的治疗效果观察［D］．哈尔滨：东北农业大学，2020.
16 柏琳，邹天琪，张成义 ．葛根总黄酮对佐剂性关节炎大鼠免疫器官指数、IL-1β及TNF-α的影响分析［J］．吉林医学，2021，42（6）：1298-1300.
  BO Lin， ZOU Tianqi， ZHANG Chengyi ．Analysis of the effects of total flavonoids of Pueraria lobata on immune organ index，IL-1β and TNF-α in rats with adjuvant arthritis［J］．Jilin Medical Journal，2021，42（6）：1298-1300.
17 章超，康建华，邹红 ．薏苡仁汤加味结合温针灸治疗风寒湿痹型类风湿性关节炎临床观察［J］．光明中医，2021，36（19）：3299-3301.
  ZHANG Chao， KANG Jianhua， ZOU Hong ．Clinical observation on coix seed decoction combined with warm acupuncture and moxibustion in the treatment of rheumatoid arthritis of wind-cold-dampness arthralgia type［J］．Guangming Journal of Chinese Medicine，2021，36（19）：3299-3301.
18 郭晋良，冯玛莉 ．中医药治疗痛风性关节炎用药经验探析［J］．光明中医，2021，36（10）：1543-1547.
  GUO Jinliang， FENG Mali ．Exploration on empirical medication of traditional Chinese medicine in the treatment of gouty arthritis［J］．Guangming Journal of Chinese Medicine，2021，36（10）：1543-1547.
19 王蕾，王宇，刘文俊，等 ．盐酸氨基葡萄糖联合硫酸软骨素治疗膝关节骨性关节炎的疗效观察［J］．医学理论与实践，2021，34（1）：79-81.
  WANG Lei， WANG Yu， LIU Wenjun，et al ．The efficacy of glucosamine hydrochloride combined with chondroitin sulfate in the treatment of osteoarthritis of the knee joints［J］．The Journal of Medical Theory and Practice，2021，34（1）：79-81.
20 王铜浩，田永刚，韩立强，等 ．姜黄素对骨质疏松鼠模型作用机制的研究［J］．医学信息，2022，35（8）：30-33.
  WANG Tong-hao， TIAN Yong-gang， HAN Li-qiang，et al ．Research on the mechanism of curcumin on the osteoporosis rat model［J］．Journal of Medical Information，2022，35（8）：30-33.
21 何晶，邱春媚，黄远英，等 ．氨糖软骨素钙姜黄复合物对骨密度的协同作用［J］．食品工业，2023，44（2）：131-134.
  HE Jing， QIU Chunmei， HUANG Yuanying，et al ．Synergistic effect of the compound of glucosamine chondroitin calcium and curcumin on bone mineral density［J］．The Food Industry，2023，44（2）：131-134.
Options
Outlines

/

〈 〉