Journal of South China University of Technology(Natural Science) >

2024 , Vol. 52 >Issue 7: 72 - 80

DOI: https://doi.org/10.12141/j.issn.1000-565X.230271

Chemistry & Chemical Engineering

Construction of a Limit Model for Isothiazolinones Migration from Children Sports Protection Articles to Sweat

  • MA Tongmei ,
  • ZHU Zhenhai ,
  • LI Qiong ,
  • HUANG Lina ,
  • HUO Weiqiang ,
  • FANG Han ,
  • LIU Zuoqi
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  • 1.School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China
    2.School of Quality and Standards Academy, Shenzhen Technology University, Shenzhen 518118, Guangdong, China
    3.Guangzhou Customs Technology Center, Guangzhou 510623, Guangdong, China
马彤梅（1973—），女，教授，博士生导师，主要从事污染物检测、团簇化学研究。E-mail： tongmei@scut.edu.cn

Received date: 2023-04-25

  Online published: 2023-06-20

Supported by

the Natural Science Foundation of Guangdong Province(2022A1515010334)

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Abstract

The physiological characteristics and behavioral patterns of infants are somewhat different from those of adults, resulting in a much higher frequency and amount of exposure to harmful chemicals than those of adults when using the same type of products. Therefore, national regulations and standards have set safety limits for harmful chemicals to protect the most vulnerable and sensitive infants. Isothiazolinone, as the common additive to improve antibacterial performance of children products, is a potential sensitizing compound that can induce allergic dermatitis. So far there is no chemical safety limit setting for it in China, while in the international existing regulations and standards, this chemical is only restricted with the total content limit. To this end, this study examined the chemical safety assessment method of infants, summarized the existing chemical safety limit model, and defined the key steps of constructing the limit model. First, dose-response data of the chemical was determined; then the dimension of the chemical limit was confirmed; after that, with the dimensional analysis method, the parameters based on product characteristics and human behavior patterns were introduced to establish the connection between the dose-response data and the chemical migration limit. On this basis, by introducing parameters of no expected sensitization inducing level, sensitization assessment factors, sweat rate and sports time, it proposed the limit model for isothiazolinones migration from children sports protection articles to sweat. Finally, the appropriate parameter values were selected based on the infant and product characteristics, and the model was applied to calculate the migration limits of the three isothiazolinones (MI, CMI and BIT) at 0.150, 0.014 and 0.150 mg/L, respectively. These migration limits are anticipated to be incorporated in the upcoming Chinese national standard Juvenile Products: General Requirements for Daily Sports Protection Articles scheduled for release by the end of 2023, which can be employed to protect of children’s skin from isothiazolinones.

Key words： children sports protection articles; isothiazolinone; chemical safety limit model; migration to sweat

Cite this article

MA Tongmei , ZHU Zhenhai , LI Qiong , HUANG Lina , HUO Weiqiang , FANG Han , LIU Zuoqi . Construction of a Limit Model for Isothiazolinones Migration from Children Sports Protection Articles to Sweat[J]. Journal of South China University of Technology(Natural Science), 2024 , 52(7) : 72 -80 . DOI: 10.12141/j.issn.1000-565X.230271

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