The pollution problem of plasticizers in water has attracted more and more attention, and the research on their testing methods is also increasing, but the research on testing different types of plasticizers at the same time is relatively rare. And most of these studies use headspace solid phase microextraction, which is difficult to ensure good extraction efficiency and low detection limit. Therefore, this paper developed a SPME-GC-MS method to test 11 plasticizers included in two types in groundwater by using immersion solid phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS). This method used 65 μm DVB/PDMS fiber, and the extraction was carried out at 80 ℃ for 50 min with a constant stirring speed of 1 000 r/min. The fiber was introduced into GC injector port, the extract was desorbed at 270 ℃ for 2.5 min and then detected by GC-MS. Qualitative analysis was performed by using retention time and characteristic ion, and quantitative by internal standard method. The results show that the linearity of 11 plasticizers is good in the range of 0.1 ~ 2.0 μg/L and the correlation coefficients are greater than 0.996; the detection limit is 0.03 ~ 0.06 μg/L; the recovery is 60.9% ~ 128.0%; and the relative standard deviation (RSD) is 6.68% ~ 19.00%. The proposed method is simple, reliable and sensitive, and it’s suitable for the determination of phthalate esters and adipate esters in groundwater. Moreover, aiming at the blank interference in plasticizer analysis, this paper conducted an in-depth study on this difficulty for the first time, carried out a detailed analysis from various aspects such as reagents, consumables and instrument maintenance, and proposed practical and operable solutions, which can effectively reduce the blank interference of plasticizers in the analysis process and further ensure the reliability of the analysis results.