The finite element model of concrete steel wire skeleton sandwich wall was established by ANSYS/LS-DYNA. The difference of displacement response of concrete steel wire skeleton sandwich wall under the action of shock wave, fragment, and a combination of the two was analyzed. And the influence of different axial compressive strength of concrete, steel wire skeleton yield strength, polystyrene foam density, angle of the inclined plug wire and arrangement, the thickness of the concrete on both sides and the bubble, the proportion of explosive distance and height and fragment size on the displacement response of concrete steel wire skeleton sandwich wall was investigated. The comparative test results show that the modeling method is reliable. The displacement of the wall under the action of single shock wave is greater than that under the action of single fragment and the combined action of the two, but the combined action of the two causes more serious damage to the wall. With the increase of the axial compressive strength of concrete and the thickness of concrete on both sides, the anti-explosion performance of the structure is enhanced. The steel wire skeleton yield strength and the density of polystyrene foam have little influence on the anti-explosion performance of the structure. The different angle and arrangement of diagonal filaments have great influence on the anti-explosion performance of the structure. The explosive height has little effect on the wall damage. When the proportional distance is fixed, the larger the explosive amount is, the more serious the wall damage will be. From the angle of wall damage, the larger the fragment size, the more serious the damage.