In view of the existing problems such as poor energy absorption and buffering capacity of concrete rigid guardrail and the danger to driving safety，a new type of prefabricated anti-collision guardrail was proposed． In order to verify its feasibility，the LS-DYNA finite element software was used to establish a guardrail-bridge deck cooperative force model to simulate the collision process of a small car and a 40 t large truck with the guardrail at different speeds． Numerical results show that the vehicle doesn＇t climb over the guardrail in collision process，the climb height and exit angle are small，and the guardrail improves guidance effects of large trucks better than that of small cars． The peak value of lateral acceleration at the driver＇s position is significantly reduced up to 60. 8% ． The peak values of the Longitudinal and lateral collision force received by the new guardrail are reduced and the longitudinal force component is reduced by up to 49. 2% ． So the new guardrail has great guiding functions and better energy absorption effects，which can effectively improve driving safety． The guardrail design can provide reference for the actual car crash test．