The accurate simulation on the wind field is an important prerequisite for the wind resistance research for the super high-rise buildings. In this research, the mesoscale WRF (Weather Research and Forecast) model, which can simulate high atmospheric circulations, and the CFD simulation, which possesses high spatial and temporal resolutions, were combined together to simulate a typical hilly area around the Shenzhen meteorological tower. Based on the WRF simulation loaded with the Four-Dimensional Data Assimilation (FDDA) technique and the CFD simulation for an equilibrium atmospheric boundary layer flow, the multi-scale wind field simulation analyses for this complex terrain were performed. The simulation result verified the applicability of the Analysis Nudging (AN) scheme and the Surface Analysis Nudging (SAN) scheme in WRF simulation, and it shows the accuracy of AN scheme is relatively higher. Compared with the separate mesoscale WRF simulation, the coupling multi-scale mo-deling results are much closer to the meteorological measurement data. The mesoscale WRF model can provide more accurate inlet boundary conditions for the small-scale CFD models and the downscale refined simulation can be rea-lized through the nesting operation in the mesh interface. Thus the simulation accuracy of the wind field can be improved by employing current multi-scale WRF-CFD simulation technique. This study indicates that the multi-scale simulation on the wind field in boundary layer based on the coupled WRF-CFD technique will be an effective way to improve the accuracy of the wind effect analysis for high-rise buildings.