In order to study the earthquake vulnerability difference of canonical structures in different intensity regions, the seismic damage data of 7099 buildings in Dujiangyan, including masonry structure, reinforced concrete frame structure and bottom frame-seismic wall masonry structure after Wenchuan earthquake, were analyzed. Considering the number of floors, coupling effect of chronological and seismic fortification factors, the probability matrices of actual seismic damage and the comparative analysis model curves of various structural types were developed. The actual seismic vulnerability matrices and its non-linear continuous regression model were constructed in different intensity zones, and the vulnerability curves of transcendence probability of actual seismic damage and seismic damage grade were drawn respectively. A vulnerability matrix model of mean seismic damage index (MSDI) was put forward, and it was verified by the actual seismic damage matrix of canonical structures. Based on the validation results, the vulnerability matrix and multi-dimensional curve model of the city based on this parameter were established.