Aiming at the inconsistence of the types of heating buildings，complexity of heating demand and high heating operation cost of central heating system at a certain college in a cold area，adjusting strategies are proposed for the energy-saving operation of optimization in central heating system of multiple buildings types． According to the heating analysis of various types of buildings and improvement of the basic equation of heating regulation，temperature control methods are proposed for building time-sharing and subarea based on partition temperature and heat exchange station pressure difference quality quantity dynamic adjustment method． The adjustment methods were applied to the real time control of a complex central heating system at the university in the 2016 －2017 heating seasons． The operation results show that in order to meet the heating demand，in comparison with the 2015 － 2016 heating seasons，2016 － 2017 heat consumption decreased by 22. 9%，electricity consumption decreased by 33. 6%，show that the proposed method is effective to optimize the operation regulation of energy saving，can provide a reference for the complex central heating system．