Accurate and effective hull surface expression and modification techniques play an important role in optimization of ship hull． Taking the DTMB5415 ship as the research object， the ship resistance performance under different Froude numbers ( Fr) was optimized with the surface modification method based on radial basis interpolation and combined with CFD calculation tool and multi-objective particle swarm algorithm． In the optimization results， three typical ship types were selected for analysis． When Fr was 0. 41， the plan 1 was better，and the wave resistance was reduced by 18. 83%． When Fr was 0. 22， the plan 3 was better，and the wave resistance was reduced by 49. 66%; when Fr was 0. 28，the plan 2 was a compromise，and the wave resistance was reduced by 30. 23%． The optimization results show that the surface deformation method based on the radial basis interpolation technique can effectively produce smooth hull profiles．