Hospital buildings require better indoor air quality and greater fresh air volume compared to other types of public buildings． Andmechanical ventilation needs large energy consumption． For Lingnan area，the indoor natural ventilation of shaft space can be well utilized by hospital buildings． The method is both environmental and energy saving． Taking hospital buildings in Lingnan for example，a computing model based on the layout of the shaft space set was built，and the wind environment during transitional seasons was analyzed by using CFD technology． The results show that the rational spatial orientation and the relative position relations of the shaft setting can improve the ventilation comfort and uniformity of hospital buildings． Even without mechanical ventilation，it can help keep human body comfortable in ventilated environment． Proper shaft space setting can effectively shorten the medical streamline，and make full use of the building land． The reasonable implantation of shaft space is also conducive to shading，which is an effective means to solve the ventilation and lighting problems between new and old buildings in the process of expansion．