This paper deals with the water resistance，compressive strength，dimensional deviation and surficial mi-crostructure of gypsum-based three-dimension printing specimens affected by filling enhancers(namely infiltrant A)，base materials of infiltrant B，dosage of waterborne epoxy emulsion in infiltrant B and immersion time． The re-sults show that(1) nano-silicone superhard curing agent is the most suitable enhancer for infiltrant A because it sig-nificantly improves the compressive strength of printing specimens; (2) waterborne polyurethane emulsion PU-202B is the most appropriate base material of infiltrant B; (3) the addition of waterborne epoxy emulsion in infiltrant B improves the compressive strength and water resistance of printing specimens，but excess waterborne epoxy emulsion may result in a dimensional deviation of the specimens; (4) the best immersion time for the three-dimension print-ing specimens into infiltrants A and B is 130s and 35s，respectively; and (5) after being immersed in infiltrant A and subsequently in infiltrant B，the specimens are of high compressive strength，weak water absorption，smooth surface and strong bond capability．