According to the data of ionospheric scintillation and total electron content (TEC) observed from January,2011 to December,2012 by a monitor set at Shenzhen Station as a part of Meridian Space Weather Monitoring Pro-ject in equatorial anomaly regions in South China,the relationship between the TEC depletion and the ionosphericscintillation at the nighttime in South China was analyzed.The results show that (1) there occurs frequent TEC de-pletion simultaneously with the scintillation; (2) the simultaneous occurrence of strong scintillation (S₄ ＞0.6) andTEC depletion is more frequent than that of weak scintillation (0.2 ＜ S₄ ≤0.6) and TEC depletion; (3) when thesimultaneous occurrence appears,a positive duration correlation with a coefficient of 0.97 apparently exists betweenthe TEC depletion and the ionospheric scintillation, and a positive correlation with a coefficient of 0.68 between the ROTI index and the S 4 index also exists; (4) the maximum TEC depletion value is linear to the product of the scin-tillation duration and the maximum S 4 value; and (5) although TEC enhancements are observed at the nighttime inSouth China,they have no significant correlation with the ionospheric scintillation.