Journal of South China University of Technology(Natural Science Edition) ›› 2012, Vol. 40 ›› Issue (10): 51-58.doi: 1000-565X(2012)10-0051-08

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Biomimetic Artificial Bone Repair Materials: a Review

Wang Ying-jun1,2  Du Chang1,2  Zhao Na-ru1,2  Ye Jian-dong1,2  Chen Xiao-feng1,2   

  1. 1. School of Materials Science and Engineering,South China University of Technology,Guangzhou 510640,Guangdong,China;2. National Engineering Research Center for Tissue Restoration and Reconstruction,Guangzhou 510006,Guangdong,China
  • Received:2012-08-01 Revised:2012-07-26 Online:2012-10-25 Published:2012-09-01
  • Contact: 王迎军(1954-) ，女，博士，教授，博士生导师，主要从事生物医用材料研究． E-mail:imwangyj@ scut.edu.cn
  • About author:王迎军(1954-) ，女，博士，教授，博士生导师，主要从事生物医用材料研究．
  • Supported by:

    国家"973”计划项目( 2012CB619100， 2011CB606204) ; 国家自然科学基金资助项目( 50830101， 51072056) ; NSFC-广东省自然科学联合基金资助项目( U0834003)

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Abstract:

The bone repair material is one of the biomedical materials with the highest clinical demand. Owing to the limitations of autograft and allograft transplantation,the development of advanced artificial bone repair materials proves to be of great significance. Novel biomimetic artificial bone repair materials can be produced by mimicking the composition and structure characteristics of natural bone and its biomineralization to design and regulate the composition and structure of the material,which has become one of the major trends in the development of biomaterials. This paper summarizes the research progress of the biomimetic artificial bone repair materials,with the focus on the authors'studies on the biomimetic synthesis of bone-like nanoscale calcium phosphate minerals,the fabrication of biomedical polymeric biomimetic nanofibrous scaffold,and the construction of the self-setting calcium phosphate cements-based bone repair materials with biomimetic porous structure.

Key words: biomedical material, bone repair material, biomineralization, biomimetic synthesis

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