Improvement Effects of Co-administration of Cartilage Extract, Turmeric Extract, Pueraria Lobata and Coix Seed Extract on Cartilage Damage of Rats with Knee Osteoarthritis

doi:10.12141/j.issn.1000-565X.220815

Abstract

Abstract:

This paper studied the synergistic effects of turmeric extract, cartilage extract, Pueraria lobata and Coix (Coix lacryma-jobi) seed extract alone and the combination on the improvement of cartilage damage of rats with knee osteoarthritis. The synergistic effects of the three extracts in rat knee osteoarthritis were evaluated mainly by reducing knee swelling (inflammation), protecting chondrocyte and repairing joint cartilage. The results show that the turmeric extract has a more obvious effect in inhibiting joint swelling and improving cartilage damage, which is specifically manifested in the ability to better improve the levels of Collagen Ⅱ, matrix metalloproteinase 3 (MMP3), cartilage oligomeric matrix protein (COMP), tumor necrosis factor-alpha (TNF-α) and superoxide dismutase (SOD). The cartilage extract significantly improves the arthritic lesions by improving the levels of MMP3, COMP, TNF-α, prostaglandin E2 (PGE2) and SOD. Pueraria lobata and Coix seed extract improves the levels of Collagen Ⅱ and SOD, inhibits the elevation of MMP3, COMP, TNF-α and interleukin 1β (IL-1β), and improves cartilage damage of rats with knee osteoarthritis. The combined use of the three extracts exhibits better effects on the repair of rat knee cartilage. These data imply that by optimizing the ratio of turmeric extract, cartilage extract and Pueraria lobata and Coix seed extract, functional foods can be developed with significant anti-inflammatory and cartilage repairing effects and contribute to the realization of “Healthy China 2030”.

Key words: cartilage extract, turmeric exact, Pueraria lobata and Coix seed extract, knee osteoarthritis, cartilage repair

CLC Number:

R684.3

DING Liugang, GUAN Ting, MIAO Jindian, et al. Improvement Effects of Co-administration of Cartilage Extract, Turmeric Extract, Pueraria Lobata and Coix Seed Extract on Cartilage Damage of Rats with Knee Osteoarthritis[J]. Journal of South China University of Technology(Natural Science Edition), 2024, 52(4): 17-25.

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