Journal of South China University of Technology(Natural Science Edition) ›› 2004, Vol. 32 ›› Issue (10): 80-84.

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Relationship Between the Substitution Degree and the Anticoagulation Activity of Cellulose Sulfate Sodium

Wang Zhao- mei Li Lin Hu Song- qing Chen Ling Guo Si- yuan   

  1. College of Food and Biological Engineering‚South China Univ．of Tech．‚Guangzhou510640‚Guangdong‚China
  • Received:2004-02-04 Online:2004-10-20 Published:2015-09-08
  • Contact: 王兆梅（1974－）‚女‚博士‚讲师‚主要从事生物多糖分离与活性方面的研究． E-mail:wangzm＠scut.edu.cn
  • About author:王兆梅（1974－）‚女‚博士‚讲师‚主要从事生物多糖分离与活性方面的研究．

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Abstract:  Cellulose sulfate sodium （Na-CS MC ） is of excellent anticoagulation activity．In order to study the structure-activity relationship between the anticoagulation activity and the substitution degree （ D S ） of Na-CS MC ‚a chemical stock of Na-CS MC analogues with different D S values must be established．In this paper‚Na-CS MC samples with differ-ent D S values and the same relative molecular mass were obtained by means of acid hydrolysis and chromatography separation．The effect of the substitution degree of Na-CS MC on the anticoagulation activity and the inhibition of coagu-lation factors was also investigated．The results indicate that both the prolongation of activated partial thrombo-plastin time and thrombin time and the inhibition to the two anticoagulation factors （Ⅱaand Xa） caused by Na-CS MC improve with the increasing of D S value within a certain range．

Key words:  cellulose sulfate sodium, anticoagulation, substitution degree, chromatography separation