Abstract:

Ibuprofen solid lipid microparticles (SLMs) were prepared by means of high-shear emulsification , and the effects of emulsification temperature , cooling temperature , stirring rate and initial drug content on the performance of SLM were investigated. The results show that the mean diameter of SLM slightly decreases and the monodispersity becomes better with the increase in emulsification temperature and stirring rate and with the decrease in cooling temperature , that the entrapment efficiency of ibuprofen in SLM becomes greater in low emulsification and cooling temperatures , and that the initial drug content has little effect on the mean diameter , the monodispersity and the entrapment efficiency. Moreover , it is found that , in the optimal conditions , namely , an emulsification temperature of 85 ℃ , a cooling temperature of 5  ℃, a stirring rate of 12000 r/min and an initial drug content of 10% , ibuprofen SLM with good monodispersity and a prolonged drug release time from 3 h to 12 h can be prepared , and the mean diameter and entrapment efficiency achieve (3.81 ±0. 12)μm and 91. 35% ±1. 18% , respectively.

Key words: lipids, emulsification, microparticle, ibuprofen, preparation