水中塑化剂的污染问题已经引起越来越多的关注，关于其测试方法的研究也日益增多，但将不同类别的塑化剂同时进行测试的研究比较少见，且目前大多采用顶空式固相微萃取，难以保证较好的萃取效率和较低的检出限。为此，文中建立了一种浸入式固相微萃取-气相色谱-质谱法（SPME-GC-MS）来测定地下水中11种共两大类别的塑化剂。该方法选用65 μm二乙烯基苯/聚二甲基硅氧烷（DVB/PDMS）萃取纤维，在1 000 r/min的磁力搅拌转速下，于80 ℃萃取50 min，然后将萃取头直接注入GC进样口，于270 ℃下热解析2.5 min，再采用气相色谱-质谱联用仪进行检测，以保留时间和特征离子进行定性，以内标法进行定量。实验结果表明，11种塑化剂在0.1 ~ 2.0 μg/L范围内线性关系良好，相关系数大于0.996，检出限为0.03 ~ 0.06 μg/L，回收率为60.9% ~ 128.0%，相对标准偏差为6.68% ~ 19.00%。文中方法简便可靠，灵敏度高，适用于地下水中邻苯二甲酸酯类和己二酸酯类塑化剂含量的测定。针对塑化剂分析中的空白干扰问题，文中首次从试剂、耗材及仪器维护等各方面进行了详尽的分析，提出了切实可操作的解决方案，有效地降低了分析过程中塑化剂的空白干扰，进一步确保了分析结果的可靠性。

The pollution problem of plasticizers in water has attracted more and more attention, and the research on their testing methods is also increasing, but the research on testing different types of plasticizers at the same time is relatively rare. And most of these studies use headspace solid phase microextraction, which is difficult to ensure good extraction efficiency and low detection limit. Therefore, this paper developed a SPME-GC-MS method to test 11 plasticizers included in two types in groundwater by using immersion solid phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS). This method used 65 μm DVB/PDMS fiber, and the extraction was carried out at 80 ℃ for 50 min with a constant stirring speed of 1 000 r/min. The fiber was introduced into GC injector port, the extract was desorbed at 270 ℃ for 2.5 min and then detected by GC-MS. Qualitative analysis was performed by using retention time and characteristic ion, and quantitative by internal standard method. The results show that the linearity of 11 plasticizers is good in the range of 0.1 ~ 2.0 μg/L and the correlation coefficients are greater than 0.996; the detection limit is 0.03 ~ 0.06 μg/L; the recovery is 60.9% ~ 128.0%; and the relative standard deviation (RSD) is 6.68% ~ 19.00%. The proposed method is simple, reliable and sensitive, and it’s suitable for the determination of phthalate esters and adipate esters in groundwater. Moreover, aiming at the blank interference in plasticizer analysis, this paper conducted an in-depth study on this difficulty for the first time, carried out a detailed analysis from various aspects such as reagents, consumables and instrument maintenance, and proposed practical and operable solutions, which can effectively reduce the blank interference of plasticizers in the analysis process and further ensure the reliability of the analysis results.