To investigate the seismic performance of end-bearing steel tube-reinforced concrete column base, five specimens were designed for pseudo-static test, considering the differences of axial compression ratio and anchor reinforcement ratio. The seismic failure mode of column base was investigated, and the evolution law of seismic performance indexes was analyzed, such as hysteresis curves, ductility, stiffness degradation, strength degradation and energy dissipation capacity. The test results show that five specimens all fail in bending failure. The axial compression ratio has a significant impact on seismic performance indexes of column base, but the anchor reinforcement ratio has no obvious influence on stiffness degradation or strength degradation of column base near the balanced failure point. Each specimen has a full hysteresis curve, good energy dissipation capacity, stable bearing capacity and good ductility, and the stiffness decreases slowly after yielding. This demonstrates the excellent seismic performance of end-bearing steel tube-reinforced concrete column base, meeting the requirements of seismic design. In the late elastic stage, the strain distribution of end-bearing steel tube-reinforced concrete column base section deviates from the plane-section assumption when the steel tube is in tension. This phenomenon can be improved by increasing the anchor reinforcement ratio.