为了探讨二氢杨梅素( DMY) 对荷瘤小鼠阿霉素( ADM) 化疗的增效减毒作用，建立4T1 乳腺癌细胞Balb /C 雌性小鼠体内移植肿瘤模型，观察DMY 和ADM 单用以及联合干预对小鼠移植瘤重、肺部转移灶和心肝毒性的影响．结果发现: 与对照组( 生理盐水溶液) 相比，100mg /( kg·d) 的DMY 对荷瘤小鼠瘤重及肌酸激酶、谷丙转氨酶和谷草转氨酶( AST) 水平无显著影响，但能显著减少血清乳酸脱氢酶( LDH) 水平( P ＜ 0. 05) 和肺部转移灶数( P ＜ 0. 01) ; 2 mg /( kg·d) 的ADM 能显著减小瘤重( P ＜ 0. 05) 和肺部转移灶数( P ＜ 0. 01) ，并能显著增加血清LDH 和AST 水平( P ＜ 0. 05) ; 2 mg /( kg·d) 的ADM 和100mg/( kg·d) 的DMY 联合使用具有更佳的抗肿瘤效果，能同时显著减少瘤重和肺部转移灶数( P ＜ 0. 01) ，并能减少ADM 单独使用所诱导的LDH 和AST 增加量．以上结果说明，ADM 对小鼠移植性4T1 乳腺癌生长和肺转移有明显的抑制作用，但伴随一定程度的心、肝毒性; DMY 对ADM 的抗肿瘤作用具有增效减毒作用．

In order to explore the synergy and attenuation effects of dihydromyricetin ( DMY) on the tumor-bearing mice affected by breast cancer treated with adriamycin ( ADM),a model of transplanted 4T1 was established in the female Balb /C mice. Then,the effects of DMY alone,ADM alone and ADM combined with DMY on the mass of the transplanted tumor,the lung metastatic loci,the cardiotoxicity and the hepatotoxicity were studied. The results
show that,as compared with the control group ( physiological saline) ,100 mg /( kg·d) DMY has no significant effect on the tumor mass as well as the creatine kinase,the alanine transaminase and the aspartate aminotransferase ( AST) activities,but significantly reduces the serum lactate dehydrogenase ( LDH) activity ( P ＜ 0. 05) and the lung metastatic loci ( P ＜ 0. 01) ,that 2 mg /( kg·d) ADM significantly decreases the tumor mass ( P ＜ 0. 05) and the lung metastatic loci ( P ＜ 0. 01) but significantly increases the LDH and AST activities ( P＜0. 05) ,and that 2mg /( kg·d) ADM combined with 100mg /( kg·d) DMY brings about better antitumor effect,that is,not only the tumor mass and the lung metastatic loci but also the increments of the LDH and AST activities induced by ADMalone decrease,with a significance level of P ＜ 0. 01 for the former. The above-mentioned details indicate that ADM can significantly inhibit the growth and lung metastasis of transplanted 4T1 in tumor-bearing mice,although it may result in cardiotoxicity and hepatotoxicity to a certain degree,and that DMY can enhance the antitumor effects of ADM and attenuate adriamycin-induced cardiotoxicity and hepatotoxicity.