采用可溶粒子造孔法,结合冷等静压成型技术,分别以立方体的氯化钠晶体和短棒状的谷氨酸钠晶体为造孔粒子制备出具有较高孔隙率和良好抗压强度的磷酸钙骨水泥组织工程支架材料,通过X射线衍射分析、扫描电镜分析及力学性能测试,研究了所制备的支架材料的物相组成及颗粒形貌对支架材料显微结构和力学性能的影响.结果表明：两种造孔粒子制得的支架材料的主晶相均是弱结晶的羟基磷灰石;造孔粒子的形貌决定了所制备的支架的孔隙形貌,并影响支架的孔隙率和力学性能;在造孔粒子加入量相同的情况下,谷氨酸钠晶体作为造孔粒子制备的支架的孔隙率更高,但强度更低;由于在制备过程中引入了等静压处理,支架材料具有良好的强度.

Calcium phosphate cement（CPC） scaffolds with large porosities and high compressive strength were prepared for bone tissue engineering via the soluble salt-leaching method combined with the cold isostatic pressing treatment,with cubic sodium chloride and rod-like monosodium glutamate crystals as porogens,respectively.Then,the phase composition of the scaffolds was analyzed by XRD and the effect of porogenmorphology on the microstructure and mechanical property of the scaffolds was investigated by means of SEM and mechanical tests.The results indicate that（1） the major phase of the scaffolds prepared with the two above-mentioned porogens are both poorly crystalline hydroxyapatite;（2） the shape of macropores in the scaffolds depends on the porogen morphology that affects the porosity and mechanical property of the scaffolds;（3） with the same dosage of porogen,the porosity of the scaffold prepared with monosodium glutamate crystals is higher than that of the scaffold prepared with sodium chloride crystals,while the compressive strength is lower;and（4） the cold isostatic pressing treatment results in high compressive strength of the scaffolds.