针对糖尿病慢性伤口感染难控、炎症持续、愈合缓慢的临床痛点，本研究以生物相容性优异的聚乙烯吡咯烷酮（PVP）和聚乙烯醇缩丁醛（PVB）为基材，通过氨基化修饰优化碳纳米洋葱（CNO）表面性能，采用静电纺丝技术制备PVP/PVB/NH₂-CNO复合纤维膜。系统表征材料的理化性质、生物相容性，并评价其抗菌、抗生物膜、抗氧化及抗炎等多功能协同修复性能。结果表明：氨基化修饰成功在CNO表面引入氨基官能团，NH₂-CNO呈现类球形结构与多级孔特征，光热转化效率达60.8%且循环稳定性优异；PVP/PVB/NH₂-CNO纤维膜结构连续均一，疏水性可控，细胞存活率>80%，溶血率<5%，符合医用材料生物安全标准；在808 nm近红外激光照射下，材料通过"静电+光热"协同作用，对大肠杆菌和耐甲氧西林金黄色葡萄球菌（MRSA）杀菌率显著提升，且能有效抑制MRSA生物膜形成；同时具备显著的DPPH自由基清除能力与细胞内活性氧（ROS）清除功能，可下调促炎因子（TNF-α、IL-6、IL-1β）表达，上调抗炎及修复相关基因（IL-10、TGF-β1、Arginase1）表达。本研究制备的PVP/PVB/NH₂-CNO复合纤维膜实现了抗菌、抗生物膜、抗氧化、抗炎多功能协同，为糖尿病慢性伤口修复敷料的开发提供了新方案。

Aiming at the clinical pain points of diabetic chronic wounds (difficult infection control, persistent inflammation, slow healing), this study used biocompatible polyvinylpyrrolidone (PVP) and polyvinyl butyral (PVB) as substrates, optimized carbon nano-onions (CNO) via amination modification, and prepared PVP/PVB/NH₂-CNO composite fibrous membranes by electrospinning. The material’s physicochemical properties, biocompatibility, and multifunctional repair capabilities were characterized and evaluated. Results showed amino groups were successfully introduced into CNO; NH₂-CNO had a quasi-spherical structure, hierarchical pores, 60.8% photothermal conversion efficiency, and good cycling stability. The fibrous membrane had a uniform structure, controllable hydrophobicity, cell viability >80%, hemolysis rate <5% (meeting medical biosafety standards). Under 808 nm near-infrared laser, it enhanced bactericidal rate against Escherichia coli and MRSA via "electrostatic force + photothermal effect", inhibited MRSA biofilm formation, scavenged DPPH free radicals and intracellular ROS, regulated inflammatory factor and repair-related gene expression. This membrane achieves multi-functional synergy, providing a new strategy for diabetic chronic wound dressings.