婴童的生理特征和行为模式与成人存在一定差异，导致其在使用相同类型产品时，对有害化学物质的暴露频率及暴露量远高于成人。因此，各国法规标准对婴童用品设置了有害化学物质的安全限值，用以保护最脆弱且敏感的婴童群体。异噻唑啉酮是一种能引起过敏性皮炎的强致敏性化合物，国内尚未设置其化学安全限值，国外也仅限于对其总含量的限制。为此，文中通过考察婴童的化学安全评估方法，总结现有化学安全限值模型，明确了构建限值模型的关键步骤。首先确定剂量反应数据；接着根据产品使用特征确定限值的量纲；然后基于量纲分析法，引入产品特征和人体行为模式参数，建立剂量反应数据与限值之间的联系。在此基础上，通过引入致敏阈值、总致敏评估因子、出汗率、运动时长构建了婴童运动护具中异噻唑啉酮汗液迁移限值模型。最后，结合婴童及产品特征选择合适的参数值，并应用该模型计算出3种异噻唑啉酮（MI、CMI和BIT）的迁移限值，分别为0.150、0.014和0.150 mg/L。该值拟在2023年底公布的国家标准《婴童用品 日常运动防护器具通用技术要求》中被应用，用以保障婴童皮肤免受异噻唑啉酮的危害。

The physiological characteristics and behavioral patterns of infants are somewhat different from those of adults, resulting in a much higher frequency and amount of exposure to harmful chemicals than those of adults when using the same type of products. Therefore, national regulations and standards have set safety limits for harmful chemicals to protect the most vulnerable and sensitive infants. Isothiazolinone, as the common additive to improve antibacterial performance of children products, is a potential sensitizing compound that can induce allergic dermatitis. So far there is no chemical safety limit setting for it in China, while in the international existing regulations and standards, this chemical is only restricted with the total content limit. To this end, this study examined the chemical safety assessment method of infants, summarized the existing chemical safety limit model, and defined the key steps of constructing the limit model. First, dose-response data of the chemical was determined; then the dimension of the chemical limit was confirmed; after that, with the dimensional analysis method, the parameters based on product characteristics and human behavior patterns were introduced to establish the connection between the dose-response data and the chemical migration limit. On this basis, by introducing parameters of no expected sensitization inducing level, sensitization assessment factors, sweat rate and sports time, it proposed the limit model for isothiazolinones migration from children sports protection articles to sweat. Finally, the appropriate parameter values were selected based on the infant and product characteristics, and the model was applied to calculate the migration limits of the three isothiazolinones (MI, CMI and BIT) at 0.150, 0.014 and 0.150 mg/L, respectively. These migration limits are anticipated to be incorporated in the upcoming Chinese national standard Juvenile Products: General Requirements for Daily Sports Protection Articles scheduled for release by the end of 2023, which can be employed to protect of children’s skin from isothiazolinones.