以H-β分子筛为载体制备了高分散性的CuO-Bi2O3/H-β催化剂，在水体系中催化乙酰丙酸（LA）脱羧制备丁酮（MEK）和丙酮（Ace）。考察了影响LA脱羧性能的反应因素，对催化剂进行了表征。在290℃、初始pH=5~6的体系中，24CuO-12Bi2O3/H-β催化LA脱羧反应3h，LA转化率达88.06%，MEK产率达40.75%，MEK和Ace的总产率达61.05%，说明该催化剂不仅脱羧活性高，而且具有较好的循环使用性能。表征分析发现，24CuO-12Bi2O3/H-β兼具中强酸、中强碱及弱酸、弱碱位点，Bi元素的引入促进了CuO在载体上的分散，Cu/Bi组分起到了协同催化脱羧作用。

CuO-Bi2O3/H-β catalyst with high dispersion was prepared by taking H-β molecular sieve as the carrier，and butanone （MEK） and acetone （Ace） were prepared via the decarboxylation of levulinic acid （LA）.Then，the parameters affecting the decarboxylation performance of LA were investigated and the catalysts were characterized．Under the condition of 290℃，initial pH 5~6 and decarboxylation reaction for 3h，the conversion rate of LA can reach 88.06%，the yield of MEK can reach 40.75%，and the total yield of MEK and Ace can reach 61.05%.The research results show that the catalyst has high decarboxylation activity and excellent recycling performance.Moreover，the characterization results show that CuO-Bi2O3/H-β possesses both weak acid-base sites and medium-strong acid-base sites，and the introduction of Bi element promotes the dispersion of CuO in the carrier，and that the Cu/Bi component plays a synergistic catalytic decarboxylation role.