结合夏热冬暖地区的气候特征，建立了一间洁净室的物理模型，采用谐波反应法对净化空调系统逐时冷、湿负荷进行了数值计算，分析围护结构和空气处理过程对冷负荷的影响，并将模型计算结果与实际工况进行了对比验证．结果表明:外遮阳装置的节能潜力较大，室内逐时冷负荷下降幅度最大可达13．6%;相同外界条件下，与一次回风处理过程相比，独立新风系统节能效果明显，节能率最大可达38．3%;与测试结果比较，冷负荷计算值平均误差为10%，表明所建立的模型可靠．

According to the characteristics of the climate in a zone with hot summer and warm winter,a physicalmodel of a clean room was built.Then,based on the harmonic response method,a numerical calculation of thehourly cooling and moisture load in the modeled clean room with a clean air conditioning system was carried out.Moreover,the effects of the building envelope and the hydrothermal process on the hourly cooling load were ana-lyzed,with the results being finally compared with the actual operation data.It is found that (1) the exterior win-dow shades are of great energy- saving potential,with an indoor hourly cooling load reduction being up to 13.6%;(2) under the same external conditions,the dedicated outdoor air system is superior to the primary return air sys-tem,with a maximum energy- saving rate being up to 38.3%; and (3) the average calculation error of cooling loadis only 10%,which means that the established physical model is reliable.